Molecular genetics of affective disorders
نویسندگان
چکیده
منابع مشابه
Genetics of affective disorders.
Despite substantial evidence for heritability in affective disorders the contributing genes have proven elusive. Here we discuss the genetic epidemiology of depression, as well as methodological issues and results from molecular genetic studies. There has been rapid advances in genetics, genomics and statistical modelling, facilitating the search for molecular mechanisms underlying affective di...
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I review evolutionary-genetic models for the generation, maintenance and loss of allelic variation underlying polygenic disease, in the context of affective disorders and related conditions. Genetically-based liability to these disorders appears to be due to some combination of mutation-selection balance involving common, small-effect variants and rare, large-effect variants, and natural select...
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As shown by clinical genetic studies, affective and anxiety disorders are complex genetic disorders with genetic and environmental factors interactively determining their respective pathomechanism. Advances in molecular genetic techniques including linkage studies, association studies, and genome-wide association studies allow for the detailed dissection of the genetic influence on the developm...
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Twenty five human peroxisomal disorders have been defined at this time. They are subdivided into two major categories: 1) the disorders of peroxisome biogenesis, in which the organelle fails to form normally, and there are defects that involve multiple peroxisomal functions; and 2) disorders that affect single peroxisomal enzymes. During the last five years the molecular defects have been ident...
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ژورنال
عنوان ژورنال: The International Journal of Neuropsychopharmacology
سال: 2003
ISSN: 1461-1457,1469-5111
DOI: 10.1017/s1461145703003420